Indications and Important Safety Information

The RHA® collection of resilient hyaluronic acid (HA) fillers includes RHA® 2, RHA® 3 and RHA® 4. RHA® 2 and RHA® 3 are indicated for injection into the mid-to-deep dermis for the correction of moderate to severe dynamic facial wrinkles and folds, such as nasolabial folds; and RHA® 4 is indicated for injection in the deep dermis to superficial subcutaneous tissue for the correction of moderate to severe dynamic facial wrinkles and folds, such as nasolabial folds; in adults 22 or older.READ MORE

Beauty is Dynamic,
Not Static

The RHA® Collection brings you the fourth dimension because it is designed to adapt to facial dynamics.

RHA® has a unique combination of stretch and dynamic strength that makes it resilient enough to accompany, rather than endure, the demands of a constantly moving face.

Introducing

Dynamics: The 4th Dimension of Facial Aesthetics

1st
2nd
3rd

4th

1st
Reduce Wrinkles

First Dimension: HA fillers addressed static wrinkles and folds at rest

2nd
Restoring Volume

Second Dimension: HA fillers were engineered to restore volume at rest

3rd
Addressing Static Facial Expressions

Third Dimension: HA fillers addressed static expressions

4th

Dynamic Facial Movement

Fourth Dimension: RHA is designed to adapt to facial dynamics

Preserved Network Technology is the latest innovation in HA filler science

RHA® is designed to resemble natural HA

The RHA® Collection is made with a gentle manufacturing process. Reduced crosslinking allows gel to move dynamically and accompany – rather than endure – the harsh strains of facial dynamics and thus provide durable outcomes.

Closely mimics natural HA and still achieves:
  • A natural look at rest and in motion
  • Proven clinical effectiveness and duration up to 15 months*
  • No delayed onset treatment-related adverse events observed in the US clinical studies*
Natural HALong Hyaluronic Acid Chains
1
Preserves intrinsic non-covalent bonds
2
Low degree of BDDE modification
3

Key Benefits

  • Designed for Dynamics

    The RHA® Collection is designed to adapt to the dynamic demands of the face, for a look that’s beautiful at rest and flawless in motion.

  • Novel Manufacturing Approach to Resemble Natural HA

    TEOXANE took a novel approach and designed a hyaluronic acid filler to more closely resemble natural HA. Preserved Network Technology preserves HA chain length and their intrinsic non-covalent bonds to more closely resemble natural HA.

The RHA® Collection offers both duration and safety

Proven clinical effectiveness and duration up to 15 months*†

No delayed-onset treatment-related adverse events observed in the US clinical studies*

Clinical effectiveness and safety were demonstrated in 2 pivotal studies, each a 15-month, randomized, double-blinded, within-subject, multicenter, noninferiority, prospective trial. Study 1 (174 subjects): 74 RHA® 2/control treatment group, 74 RHA® 3/control treatment group, and 26 no-treatment group. Study 2 (140 subjects): 120 RHA® 4/control treatment group and 20 no-treatment group.

Duration based on blinded evaluator assessments at Month 15 in the 2 pivotal studies, the percentages of responders ( ≥ 1 grade improvement on the wrinkle severity rating scale) were 80.9% for RHA 2, 78.7% for RHA 3, and 89.2% for RHA 4.

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Madame Valérie Taupin

TEOXANE Founder and CEO

The excellence of Swiss science now available in the U.S. through an exclusive licensing agreement between TEOXANE and Revance.

As a leading expert in the field of beauty and aesthetics, Madame Taupin co-created the dermal filler Juvéderm two decades ago – which she went on to export to more than 50 countries worldwide.

With a singular focus on advancing HA science, Madame Taupin founded TEOXANE in Geneva, Switzerland.

Madame Taupin saw limitations with traditional Hyaluronic Acid (HA) fillers: they were engineered with a high degree of chemical modification.

She directed her research team to design a Hyaluronic Acid filler to more closely mimic HA in the skin - this introduced the latest filler innovation in the market: The RHA® Collection.

Designed for distinct patient needs

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RHA® 2

For dynamic wrinkles and folds that are moderateLearn more
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RHA® 3

For dynamic wrinkles and folds that are moderate to severeLearn more
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RHA® 4

For dynamic wrinkles and folds that are severeLearn more